The effects of acute regional ischemia during cardioplegic arrest

a comparison between normothermic and hypothermic techniques of myocardial protection.
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  • English

National Library of Canada , Ottawa
SeriesCanadian theses = -- Thèses canadiennes
The Physical Object
Pagination1 microfiche : negative. --
ID Numbers
Open LibraryOL17041885M
ISBN 100315963522

Retrograde cardioplegia (RCP) is often used for myocardial protection during coronary bypass grafting, but the regional effect of RCP in areas of evolving ischemia is unknown.

We examined the functional and metabolic indices of regional myocardial preservation following acute coronary occlusion with evolving ischemia in a canine by: 1. In an experimental study with a porcine model of acute coronary ischemia and reperfusion on cardiopulmonary bypass with cardioplegic arrest, hearts treated with GIK had a significant decrease in the incidence of ventricular arrhythmias, less tissue acidosis, better preservation of wall motion, and the lowest area of myocardial necrosis.

13 Cited by:   The Effect of Acute Coronary Artery Occlusion during Cardioplegic Arrest and Reperfusion on Myocardial Preservation John H. Rousou, M.D., Richard M. Engelman, M.D., William A.

Dobbs, Ph.D., and Mooideen K. Meeran, M.D., Ph.D. ABSTRACT A study was undertaken to evaluate the effect of acute occlusion of a coronary artery during cardioplegic arrest on myocardial Cited by: 5.

Quinaprilat during cardioplegic arrest in the rabbit to prevent ischemia-reperfusion injury 20 Lazar and coworkers, 12 in a porcine model with regional ischemia followed by acute surgical revascularization, showed beneficial The effects of acute regional ischemia during cardioplegic arrest book of systemic enalaprilat administered before cardioplegic arrest.

A reduction in infarct size, less myocardial Cited by:   Cardiovascular disease increases with age in both sexes. Treatment can require cardiac surgery, where the hearts are pre-treated with protective cardioplegic solution before ischemia and reperfusion (I/R).

While endogenous estrogen is beneficial in I/R, whether testosterone is involved is uncertain and whether age modifies responses to I/R is by: 2.

Background. Because hearts in acute myocardial infarction are often prone to ischemia-reperfusion damage during cardiac surgery, we investigated the influence of intracellular crystalloid cardioplegia solution (CCP) and extracellular blood cardioplegia solution (BCP) on cardiac function, metabolism, and infarct size in a rat heart model of myocardial infarction.

In all groups, PCR decreased immediately during ischemia and rapidly fell to low levels before recovering completely during the cardioplegic periods. Download: Download full-size image; Fig. The effect of periods of normothermic ischemia in the isolated cross-perfused canine heart during arrest by warm blood cardioplegia on PCR and ATP.

Interventions during cardioplegic arrest have also been shown to be less cardioprotective in the hypertrophic compared to the normal heart. For example, recovery of hypertrophic hearts exposed to pre-ischaemic pharmacological preconditioning and cardioplegic arrest had a lower recovery of hemodynamic parameters compared to normal Effect of annuloplasty ring implantation on tenting areas during acute myocardial ischemia: No_Ring_ISCH vs.

Ring_ISCH To date, neither clinical nor experimental in vivo studies exist comparing the effects of conventional annuloplasty rings to disease-specific FMR/IMR rings on mitral valve geometry or mitral annular dimensions during myocardial.

The proponents of this method argue that the duration of ischemia is shorter than during cardioplegic arrest (7) and that this method is as safe as cardioplegic arrest (8, 9). In our study we compared myocardial protection due to cardioplegic arrest and intermittend ischemia during coronary surgery.

Studies on prolonged acute regional ischemia. Metabolic support of remote myocardium during left ventricular power failure. J Thorac Cardiovasc Surg. Oct; 98 (4)– Naccarella FF, Weintraub WS, Agarwal JB, Helfant RH.

Download The effects of acute regional ischemia during cardioplegic arrest FB2

Evaluation of "ischemia at a distance": effects of coronary occlusion on a remote area of left ventricle. Evidence as to how ACE inhibitors attenuate ischemia-reperfusion injury (IR) after cardioplegic arrest remains scarce. Twenty-four rabbit hearts were perfused on a Langendorff apparatus.

Control hearts (n = 6) were arrested with pure histidine-tryptophan-ketoglutarate (HTK)-Bretschneider. Treatment groups received added to the cardioplegic solution (n = 6) captopril (. Studies of the effects of hypothermia on regional myocardial blood flow and metabolism during cardiopulmonary bypass.

Ferguson TB, Smith PK, Buhrman WC. Studies on the physiology of the conduction system during hyperkalemic, hypothermic cardioplegic arrest. Surg Forum –4. Structural changes in myocardium during acute.

GIK has also been shown to be effective in improving cardiac function after cardiopulmonary bypass and cardioplegic arrest (16, 24).

Despite the renewed interest in GIK as a clinical intervention in acute myocardial infarction, there is a paucity of data regarding the utility of GIK in acute myocardial ischemia without infarction.

Lofland GK., Ahd-Elfattah AS, Wyse R et al. Myocardial adenine nucleotide metabolism in pediatric patients during hypothermic cardioplegic arrest and normothermic ischemia.

Ann. Hypothermic fibrillatory arrest (HFA) was compared with conventional hypothermic cardioplegic arrest (HCA) in a model of acute regional ischemia. In 20 pigs, the left anterior descending coronary artery was occluded for 30 minutes before cardiopulmonary bypass. We investigated the effect of chronic versus acute administration of the selective endothelin-A receptor antagonist (ERA) TBCNa during ischemia/reperfusion in failing hearts.

Male Sprague. In modern cardiac surgery, crystalloid or blood cardioplegic solutions have been used widely for myocardial protection; however, ischemia does occur during protection with intermittent infusion of.

LVDP was reduced during regional ischemia in all groups. However, during ischemia the reduction in LVDP tended to be smaller in non-persistently fibrillating hearts (P=) when compared with the rest of the hearts indicating a possible link between the effects of ischemia. A key issue is the monitoring of the myocardial metabolism during the cardioplegic period during which relevant plasma sampling cannot be carried out.

Sampling of the interstitial fluid of the myocardium by means of microdialysis before, during, and after open-heart surgery is now used also in the clinical situation (18, 19). The effects of two blood concentrations of propofol on acute severe regional myocardial ischaemia (minute occlusion of the LAD coronary artery) and 2-hour reperfusion were studied in 10 pigs.

During acute myocardial ischemia the metabolism of free fatty acids is impaired. Since the rate of beta-oxidation is reduced, the levels of acil-CoA and long-chain acyl-carnitine increase. Sixty minutes of regional ischemia followed by 60 minutes of hypothermic cardioplegic arrest was designed to mimic the clinical event of acute coronary occlusion (thrombosis) leading to ischemia followed by revascularization.

The exact mechanisms of the protective effects of HSPs against cellular injury remain unknown. myocardial ischemia is a life-threatening event that involves a mismatch between oxygen supply and demand.

Details The effects of acute regional ischemia during cardioplegic arrest EPUB

It can occur in many contexts including atherosclerosis, coronary artery spasm, vasculitis, and during cardiac surgery with cardiopulmonary bypass (CPB) (17, 34).Ischemia initiates several biological processes including altered metabolism, initiation of apoptosis, necrosis and fibrosis.

This study sought to determine the optimal timing for NO supplementation in the setting of cardioplegic arrest, regional ischemia, and reperfusion.

Isolated working rat hearts were arrested with. Hypothermia, Induced Subject Areas on Research. Ischemic Preconditioning: Definition and Experimental Models. Although ischemic preconditioning initially referred to the ability of short periods of ischemia to limit infarct size, 1 some investigators extended this definition to include a beneficial effect on ischemia- and reperfusion-induced arrhythmias 2 and on myocardial stunning.

3 It is questionable, however, whether the reduction in. The effect of cardiopulmonary bypass resuscitation on cardiac arrest induced lactic acidosis in dogs.

Description The effects of acute regional ischemia during cardioplegic arrest FB2

Resuscitation ; 31) Ornato JP, Levine Rl, Young DS, et al. The effect of applied chest compression force on systemic arterial pressure and end tidal carbon dioxide concentration during CPR in human beings. LV contractility was depressed during ischemia (− ± %, p ≪ vs baseline) as well as following cardioplegic arrest Reduction of myocardial reperfusion injury by aprotinin after regional ischemia and cardioplegic arrest.

J Thorac Cardiovasc Surg. Google Scholar. Kofsky ER, Julia PL, Buckberg GD, Quillen JE, Acar C. Studies of controlled reperfusion after ischemia.

XXII. Reperfusate composition: effects of leukocyte depletion of blood and blood cardioplegic reperfusates after acute coronary occlusion. J Thorac Cardiovasc Surg. ;–9. PubMed Google Scholar. abstract. Study objective – The aim of the study was to investigate the effect of reperfusion with adenosine after prolonged cardioplegic arrest in the isolated working rat heart.

Design – After 3 h of hypothermic (20°C) ischaemic arrest with multidose (every 30 min) infusions of St Thomas's Hospital cardioplegic soluton No 1, rat hearts were reperfused with either ordinary perfusion.Reperfusion Injury Subject Areas on Research.Background: Cardiomyocyte apoptosis might contribute to left ventricular (LV) dysfunction following cardiac surgery.

Magnetic resonance imaging is considered the most accurate method of determining LV function. We compared apoptosis (by terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling, TUNEL, staining and detection of caspase 3.